The drugs used to treat malaria include quinine, pyrimethamine, sulfadiazine, chloroquine phosphate and chloroquine sulfate, mefloquine, and tetracycline. Some malaria-causing parasites have become resistant to these drugs. Many of these drugs have significant side effects, also.

"Patients with P. falciparum malaria also are treated with sponging and aspirin to lower fever and relieve headache. At the same time, doctors should watch them closely for potentially severe complications, including anemia (a blood disorder created by the extensive destruction of red blood cells); kidney failure; fluid imbalance; or brain damage (cerebral malaria) produced when large numbers of red blood cells containing parasites clog tiny blood vessels in the brain. The doctor can treat patients with severe complications with intravenous (directly into the vein) or oral quinine." National Institute of Health - Treating Malaria
https://www.niaid.nih.gov/publications/malaria/treat.htm

Technical explanation of treatment